The 4th International Conference on Frontiers in Computing and Systems (COMSYS-2023) will be held during October 16-17, 2023, at Indian Institute of Technology Mandi, Himachal Pradesh, India, to be jointly organized by the School of Computing and Electrical Engineering (SCEE) and COMSYS Educational Society, Kolkata at Indian Institute of Technology Mandi (IIT Mandi). The main objective of COMSYS-2023 is going to present the latest research and results of scientists with a theme “Cyber-physical Systems for real-life applications” pertaining to Artificial Intelligence, Machine Learning & Data Science; Devices, Circuits and Systems; Computational Biology and Bioinformatics; Image, Video, and Signal Processing; Communication Networks, Cloud computing, Security, and IoT. This conference provides opportunities for delegates from different areas to exchange new ideas and application experiences face-to-face to establish academic or research collaborations. It will bring together researchers from academia and industry onto a common platform and help them to develop a comprehensive understanding of the challenges of technological advancements from different viewpoints. This conference will also help foster a healthy and vibrant relationship between academia and industry.